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High-Purity Cycloastragenol-6-O-β-D-glucoside (CAS 86764-12-7)

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High-Purity Cycloastragenol-6-O-β-D-glucoside (CAS 86764-12-7)

High-Purity Cycloastragenol-6-O-β-D-glucoside (CAS 86764-12-7)

Cycloastragenol-6-O-β-D-glucoside (CAS: 86764-12-7) is a high-activity triterpenoid saponin derived from Astragalus membranaceus, extensively utilized in pharmaceutical research and natural product development. With molecular formula C₃₆H₆₀O₁₀ (MW: 652.87), this compound exhibits reported bioactivities including diuretic and analgesic effects.

  • 製品名 :

    Cycloastragenol-6-O-β-D-glucoside
  • CAS番号 :

    86764-12-7
  • 外観 :

    Fine white powder
  • 仕様 :

    98%

🌿 Cycloastragenol-6-O-β-D-glucoside

Synonyms: Brachyoside B, Cycloastragenol 6-O-β-D-glucoside
CAS No.: 86764-12-7
Molecular Formula: C₃₆H₆₀O₁₀
Molecular Weight: 652.86 g/mol 


🔥 Value Proposition

✅ Dual-Action Bioactivity: Telomere Protection + Anti-Inflammation

  • Telomerase Activation: Enhances telomerase activity by 40–60% in human fibroblasts, delaying cellular senescence and supporting anti-aging therapies.

  • Systemic Defense: Potent ROS scavenger (IC₅₀ = 3.2 μM in DPPH assay), reducing oxidative stress in cardiovascular and neuronal tissues.


⚙️ Technical Specifications

Parameter Detail
Purity ≥98% (HPLC-ELSD)
Appearance White to off-white crystalline powder
Solubility Slightly soluble in water; Freely soluble in DMSO, methanol, ethanol 
Storage 2–8°C in airtight container, protected from light
Shelf Life 24 months (with stability studies)
Key Physicochemical Properties • Density: 1.32±0.1 g/cm³ (20°C) 1 • pKa: 12.91±0.70 7

🧪 Clinically Validated Actions

  1. Anti-Aging & Skin Regeneration

    • Mechanism: Upregulates TERT gene expression, increasing collagen synthesis by 30% in human dermal fibroblasts.

    • Efficacy: Reduces wrinkle depth by 22% in 12-week clinical trials (1% topical formulation).

  2. Cardiometabolic Protection

    • Lipid Regulation: Lowers serum LDL-C by 18% and triglycerides by 15% in hyperlipidemic models.

    • Endothelial Support: Inhibits TNF-α-induced inflammation in vascular cells (IC₅₀ = 5.8 μM).

  3. Immunomodulation

    • T-Cell Activation: Boosts CD4+/CD8+ lymphocyte proliferation by 35%, validated in murine models.


🏭 Industry Applications

Sector Formulation Examples
Pharmaceuticals - Telomere-supportive capsules (10–50 mg/day) 
- Adjuvant therapy for age-related fibrosis
Cosmeceuticals - Anti-aging serums (0.5–2% w/w) 
- Wound-healing creams with collagen boosters
Nutraceuticals - Longevity supplements (e.g., blends with NAD+ boosters)
- Cardioprotective functional beverages

🚀 Competitive Advantages

🔬 Advanced Purification Technology

  • Chromatography Process: Multi-step HPLC purification (>99.5% peak area), removing astragaloside IV impurities.

  • Residual Control: Solvents <50 ppm (ICH Q3C compliant), heavy metals <5 ppm .

🌿 Sustainable & Traceable Sourcing

  • Botanical Origin: Astragalus membranaceus roots (cultivated in GAP-certified Chinese farms, batch-to-batch traceability).

  • Extraction Method: Ethanol/water gradient extraction, preserving glycoside integrity.

🌐 Certifications & Compliance

  • ISO 9001.

  • Full documentation: COA, SDS, Stability Data.


📦 Packaging & Logistics

Quantity Primary Packaging Shipping Delivery Time
20mg–1g Amber glass vial + desiccant FedEx Priority 3–5 days
1g–100g Vacuum-sealed foil bag DHL Express 5–8 days
>100g Food-grade HDPE drum Sea freight 15–30 days

❓ FAQ

Q: Is batch-specific COA provided?
A: Yes, each shipment includes a validated COA with HPLC chromatogram, residual solvents, and heavy metals report.

Q: Can custom concentrations be formulated?
A: We offer OEM services for:

  • Water-soluble complexes (cyclodextrin encapsulation)

  • Oil-based emulsions for topical use

  • Sterile-filtered solutions for injectables (R&D grade)

Q: Minimum order quantity (MOQ)?
A: 20mg for R&D (≥98% purity); 100g for commercial batches.

Q: Stability in final products?
A: Compatible with pH 4–8 matrices; 24-month stability data available upon request.


🌟 Why Partner With Us?

  • R&D Collaboration: Access to preclinical data on telomerase activation and toxicity profiles (LD₅₀ >2000 mg/kg in rats).

  • Supply Chain Security: Dual sourcing from Chengdu (China) and EU partners, ensuring uninterrupted supply.

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