High-Purity (-)-Epicatechin 98% (CAS 490-46-0) | Pharmaceutical & Nutraceutical Grade

🌿 (-)-Epicatechin ≥98%
CAS: 490-46-0
Molecular Formula: C₁₅H₁₄O₆
Molecular Weight: 290.27 g/mol
Appearance: White to off-white crystalline powder

🔥 Core Value Proposition
Cardioprotective & Metabolic Flux Modulator

• ≥98% Purity: Pharmaceutical grade.

• Endothelial Function Enhancer: Activates eNOS/NO-cGMP pathway, improving vascular reactivity.

• Mitochondrial Biogenesis Inducer: Upregulates PGC-1α/FNDC5 signaling.

• Insulin Sensitizer: Potentiates GLUT4 translocation in skeletal muscle.

✅ Clinically Validated Benefits

1. Cardiovascular Health:

   • Oral 50 mg/day ↑ flow-mediated dilation (FMD) by 42% in hypertensive patients (RCT, n=40).

   • Suppresses ET-1 synthesis (↓81% at 30 μM in HUVECs).

2. Exercise Performance:

   • 1 mg/kg/day ↑ mitochondrial density by 37% and treadmill endurance by 50% in murine models.

3. Neuroprotection:

   • Reverses Aβ-induced LTP impairment (85% recovery at 10 μM) via BDNF/TrkB activation.

4. Antioxidant Power:

   • ORAC value: 24,300 μmol TE/g; regenerates α-tocopherol in LDL particles (IC₅₀: 2.1 μM).

⚙️ Technical Specifications

💊 Pharmaceutical & Nutraceutical Applications

• Cardiometabolic Formulas:
  30-100 mg sustained-release capsules for endothelial dysfunction (Phase II).

• Sports Nutrition:
  200 mg pre-workout complexes boosting exercise tolerance (VO₂max ↑14% in cyclists).

• Cognitive Health:
  150 mg/day lozenges for cerebrovascular support (MMSE score ↑3.2 points in pilot trial).

• Glycemic Control:
  5% functional chocolate modulating postprandial glucose spikes (Cmax ↓28%).

🚀 Competitive Advantages

• Stereoselective Synthesis: >99.5% enantiomeric excess via asymmetric hydrogenation.

• Bioavailability Tech:
  Phytosome® complexes achieve 3.8× ↑ Cmax (human pharmacokinetics).

• Global Compliance:

📦 Packaging & Delivery

❓ FAQ
Q: How to confirm (-)-epicatechin stereopurity?
A: Batch-specific chiral HPLC chromatograms (Chiralpak IC-3 column) included.

Q: Stability in aqueous formulations?
A: Use citrate buffer (pH 3.5) + 0.01% EDTA; retains >95% potency at 25°C/12 months.

Q: Dosing for NO activation?
A: 1-5 μM in vitro; human equivalent dose: 30-150 mg/day (allometric scaling).

🌱 Why Partner With Us?

• Traceable Botany: Sustainably wildcrafted Camellia sinensis (UTZ Certified).

• Advanced Derivatives:

  • Epicatechin-3-gallate (ECG) 95% for metabolic synergy

  • Deuterated epicatechin-d₄ for clinical tracer studies

• Nano-engineering:
  150 nm liposomes for blood-brain barrier penetration (brain Cmax ↑320%).