日本語
6-Prenylnaringenin (6-PN, CAS 68682-01-9) is a potent and reversible inhibitor of Cav3.2 T-type calcium channels (IC₅₀ = 991 nM), widely used in neuroscience and pharmacological research. It demonstrates exceptional blood-brain barrier permeability, making it ideal for studying neuropathic and visceral pain mechanisms.
製品名 :
6-Prenylnaringenin (6-PN)CAS番号 :
68682-01-9外観 :
Off-white crystalline powder仕様 :
1%-98%🌿 6-Prenylnaringenin (6-PN)
CAS No.: 68682-01-9
Molecular Formula: C₂₀H₂₀O₅
Molecular Weight: 340.37
✅ Potent Phytoestrogen with Dual Activity
6-PN combines estrogenic and antioxidant properties, offering dual benefits:
Endocrine Modulation: Binds selectively to estrogen receptors (ERα/ERβ), alleviating menopausal symptoms (e.g., hot flashes, osteoporosis) without systemic risks of conventional hormone therapy.
Oxidative Defense: Scavenges free radicals via prenyl group, protecting against UV-induced skin damage and lipid peroxidation.
| Parameter | Detail |
|---|---|
| Purity Range | 1%, 5%, 10%, 20%, 50%, ≥98% (HPLC) |
| Identification | HPLC-UV, NMR, MS |
| Storage | ≤20°C (protected from light) |
| Shelf Life | 24 months |
| Appearance | Off-white crystalline powder (≥98%) Light yellow powder (5%-50% blends) |
Menopausal Symptom Relief
Efficacy: Mimics natural estrogen activity, significantly reducing Kupperman Menopause Index scores (e.g., improved hot flashes, mood swings).
Safety Profile: Non-carcinogenic alternative to synthetic estrogens (e.g., conjugated equine estrogens), minimizing breast/endometrial cancer risks.
Cardiometabolic Health
Lipid Regulation: Lowers total cholesterol (TC) by 10–15% and LDL-C/HDL-C ratio, supporting cardiovascular health in postmenopausal women.
Dermatological Applications
Collagen Synthesis: Enhances skin elasticity by stimulating collagen production.
UV Protection: Synergizes with sunscreens to reduce oxidative damage in cosmeceuticals.
| Sector | Use Cases |
|---|---|
| Pharmaceuticals | - Menopausal health capsules (e.g., 20–50 mg/day formulations) - Osteoporosis prevention adjuvants |
| Cosmeceuticals | - Anti-aging serums (0.5–2% concentration) - Antioxidant-boosted sunscreens |
| Functional Foods | - Hormone-balancing beverages (1–5% liquid suspensions) - Metabolic health bars |
🔬 Science-Backed Customization
Synergistic Blends: Pre-optimized with resveratrol for enhanced bioavailability or vitamin E for oxidative stability.
Solvent-Free Extraction: Patented supercritical CO₂ method ensures >99% purity and eco-friendly production.
🌐 Certified Quality & Safety
Compliance: ISO 9001, Non-GMO Project Verified.
Contaminant Control: Heavy metals <10 ppm (USP/EP), residual solvents undetectable.
| Weight | Packaging | Transport | Delivery Time |
|---|---|---|---|
| 10g–5kg | Vacuum foil bags + desiccant | DHL/FedEx | 3–7 days |
| 5kg–25kg | Gas-flushed food-grade buckets | Air freight | 5–10 days |
| >25kg | Fiber drums (ISO-certified) | Sea freight | 15–45 days |
Q: How is quality verified before ordering?
A: Free samples (1–20g) provided with batch-specific Certificate of Analysis (COA) detailing purity, heavy metals, and microbial limits.
Q: What is the minimum order quantity (MOQ)?
A: 10g for ≥98% purity, 1kg for blends (5–50%).
Q: Can you support custom formulations?
A: Yes! OEM services include pH-adjusted solutions (pH 3–7), solubility-enhanced emulsions, or blend optimization.
Q: Are regulatory documents available?
A: Full dossier (Specs, SDS, Non-GMO/Allergen Statements) compliant with FDA, EFSA, and COSMOS standards.
End-to-End Traceability: Sourced from EU-certified organic hops (Alpine regions), with blockchain-supported supply chain visibility.
R&D Collaboration: Co-develop application-specific formulations backed by clinical data on estrogenic activity and safety.
ホップ（Humulus lupulus）由来、 8-プレニルナリンゲニン（8-PN） 選択的エストロゲン受容体モジュレーター（SERM）活性を持つ強力な植物性エストロゲンで、ホットフラッシュなどの更年期障害の症状を緩和し、骨の健康を促進するとともに、Akt経路の調節により運動なしで筋肉の維持をサポートする点で、大豆イソフラボンに比べて優れた効能があります。
続きを読む
出典 ホップ（Humulus lupulus L.） （ホップ）、私たちの キサントフモール 強力なプレニル化フラボノイドで、高い生理活性とホップエキスの主要活性成分として知られています。多様な産業ニーズに対応するため、複数の純度グレード（1%、5%、10%、98%）をご用意しており、高純度品は鮮やかな黄色の結晶構造を呈します。
続きを読む
イソキサントフモール ホップ（Humulus lupulus）とビールに主成分として由来する生理活性プレニルフラボノイドです。この強力な化合物は、複数のヒト癌細胞株に対して顕著な抗増殖作用を示し、in vivo（生体内）において転移性腫瘍の発生を阻害します。また、ヘルペスウイルス（HSV1/HSV2）および牛ウイルス性下痢ウイルス（BVDV）に対しても広域スペクトルの抗ウイルス活性を示すことから、医薬品および栄養補助食品研究における貴重な候補物質となっています。
続きを読む
6-Prenylnaringenin (6-PN, CAS 68682-01-9) is a potent and reversible inhibitor of Cav3.2 T-type calcium channels (IC₅₀ = 991 nM), widely used in neuroscience and pharmacological research. It demonstrates exceptional blood-brain barrier permeability, making it ideal for studying neuropathic and visceral pain mechanisms.
続きを読む
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